Abstract
20-(Hydroxymethyl)-4-methyl-4-aza-2-oxa-5 alpha-pregnan-3-one and the corresponding 3-thione were synthesized with use of 20-(hydroxymethyl)-4-methyl-4-aza-5 alpha-pregnan-3-one as the starting material. The compounds were tested in vitro for inhibition of testosterone 5 alpha-reductase and found to be weak inhibitors with Ki's in the 10(-7) range.
MeSH terms
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5-alpha Reductase Inhibitors*
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Animals
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Enzyme Inhibitors / chemical synthesis
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In Vitro Techniques
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Kinetics
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Male
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Oxidoreductases / antagonists & inhibitors*
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Pregnanes / chemical synthesis*
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Pregnanes / pharmacology
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Prostate / enzymology
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Rats
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Steroids, Heterocyclic / chemical synthesis*
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Steroids, Heterocyclic / pharmacology
Substances
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5-alpha Reductase Inhibitors
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Enzyme Inhibitors
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Pregnanes
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Steroids, Heterocyclic
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20-(hydroxymethyl)-4-methyl-4-aza-2-oxapregnan-3-one
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Oxidoreductases