DNDMH enabled C(sp3)-H nitration of aryl alkenes

Chem Commun (Camb). 2025 Jan 27. doi: 10.1039/d4cc06671e. Online ahead of print.

Abstract

C(sp3)-H bond nitration provides facile access to nitro compounds that are inaccessible through traditional nitration pathways. This work describes a C(sp3)-H bond nitration of aryl alkenes using DNDMH, a nitration reagent developed previously in our lab. Notably, this novel nitration process presents excellent regioselectivity and chemoselectivity between C(sp3)-H nitration and C(sp2)-H nitration.