Dopamine receptors and organ fibrosis

ZhongLi Liao; XueFeng Tang; Bin Yang; Jian Yang

doi:10.1016/j.bbrep.2024.101910

Dopamine receptors and organ fibrosis

Biochem Biophys Rep. 2025 Jan 6:41:101910. doi: 10.1016/j.bbrep.2024.101910. eCollection 2025 Mar.

Authors

ZhongLi Liao^{1

2}, XueFeng Tang³, Bin Yang⁴, Jian Yang¹

Affiliations

¹ Department of Clinical Nutrition, The Third Affiliated Hospital of Chongqing Medical University, Chongqing, 400030, China.
² Department of Gastroenterology, Chongqing University Cancer Hospital, Chongqing, 400030, China.
³ Department of Pathology, Chongqing General Hospital, Chongqing University, Chongqing, 400030, China.
⁴ Department of Anesthesiology, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Fujian, 361000, China.

Abstract

Organ fibrosis, considered as a major global health concern, is a pathological condition often occurring after tissue injury in various organs. The pathogenesis of fibrosis involves multiple phases and multiple cell types. Dopamine is involved in various life activities by activating five receptors (D1, D2, D3, D4, D5). Activation or loss of function of dopamine receptors has been reported to be associated with the fibrosis of several organs, such as ocular, lung, liver, heart, and kidney. In this paper, we review dopamine receptors' potential roles in organ fibrosis and mechanisms by which organ fibrosis develops or decreases when dopamine receptors function is activated or perturbed.

Keywords: Dopamine; Dopamine receptors; Fibrosis.

Publication types

Review