Non-Pharmaceutical Interventions May Attenuate Acute Exacerbations of Asthma: Experience During the COVID-19 Pandemic in Taiwan

Chun-Yu Lin; Chiung-Hung Lin; Yu-Lun Lo; Chun-Yu Lo; Hung-Yu Huang; Meng-Heng Hsieh; Yueh-Fu Fang; Tsu-Chuan Li; Shu-Min Lin; Yu-Tung Huang; Po-Jui Chang; Horng-Chyuan Lin

doi:10.2147/JAA.S488352

Non-Pharmaceutical Interventions May Attenuate Acute Exacerbations of Asthma: Experience During the COVID-19 Pandemic in Taiwan

J Asthma Allergy. 2025 Jan 20:18:59-67. doi: 10.2147/JAA.S488352. eCollection 2025.

Authors

Chun-Yu Lin^{1

2}, Chiung-Hung Lin^{1

2}, Yu-Lun Lo^{1

2}, Chun-Yu Lo^{1

2}, Hung-Yu Huang^{1

2}, Meng-Heng Hsieh^{1

2}, Yueh-Fu Fang^{1

2}, Tsu-Chuan Li^{1

2}, Shu-Min Lin^{1

2}, Yu-Tung Huang³, Po-Jui Chang^{1

2}, Horng-Chyuan Lin^{1

2

4}

Affiliations

¹ Department of Thoracic Medicine, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan.
² College of Medicine Chang Gung University, Taoyuan, Taiwan.
³ Center for Big Data Analytics and Statistics, Chang Gung Memorial Hospital, Taoyuan, Taiwan.
⁴ Department of Respiratory Therapy, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan.

Abstract

Background: Non-pharmaceutical interventions (NPIs) were widely used during the coronavirus disease 2019 (COVID-19) pandemic, however their impact on acute asthma exacerbations (AEs) is not well studied.

Methods: We had retrospectively collected patients with asthma AEs between 2019 and 2020 and retrieved data from the Chang Gung Research Database, including clinical manifestations, medications, pulmonary function, clinic and emergency department visits and hospitalizations.

Results: A total of 39,108 adult patients with asthma were enrolled, of whom 1502 were eligible for analysis. The prevalence of acute AEs significantly decreased throughout 2020 compared with 2019 after implementation of the NPI policy. The patients were categorized into four groups: Group 1, acute AEs in 2019 with influenza infection (n=692); Group 2: acute AEs in 2019 without influenza infection (n=328); Group 3: acute AEs in 2020 with influenza infection (n=268); Group 4: acute AEs in 2020 without influenza infection (n=214). The patients in group 4 were significantly older (73.3±29.1 vs 65.5±29.2, 69.7±26.2 years, p<0.01) and had significantly worse forced expiratory volume in one second/forced vital capacity ratio (70.5±13.9 vs 79.6±15.5, 72.9±18.0, p<0.01) than those in group 1 and 2, and the highest rate of oral corticosteroid prescriptions (17%, p<0.01). The patients in group 3 and 4 had significantly lower rates of oxygen therapy, ventilator use and mortality at 3 and 12 months of follow-up than those in group 1 and 2.

Conclusion: The use of NPIs during the COVID-19 pandemic in Taiwan may reduce the frequency and severity of asthma AEs. This may provide some cost-effective strategies to attenuate acute asthma AEs.

Keywords: COVID-19; asthma; non-pharmaceutical interventions.

Grants and funding

This study was supported by Chang Gung Memorial Hospital Research Project Grant (CGRPG3K0011). The funders had no role in the study design, data collection and analysis, decision to publish, or manuscript preparation.