Design, current states, and challenges of nanomaterials in anti-neuroinflammation: A perspective on Alzheimer's disease

Xinyang Hong; Tongkai Chen; Yunyun Liu; Jun Li; Dongqing Huang; Kaiyu Ye; Wanchen Liao; Yulin Wang; Mengling Liu; Ping Luan

doi:10.1016/j.arr.2025.102669

Design, current states, and challenges of nanomaterials in anti-neuroinflammation: A perspective on Alzheimer's disease

Ageing Res Rev. 2025 Jan 27:105:102669. doi: 10.1016/j.arr.2025.102669. Online ahead of print.

Authors

Xinyang Hong¹, Tongkai Chen², Yunyun Liu³, Jun Li⁴, Dongqing Huang⁵, Kaiyu Ye⁶, Wanchen Liao⁷, Yulin Wang⁸, Mengling Liu⁹, Ping Luan¹⁰

Affiliations

¹ Department of Alzheimer's Disease Clinical Research Center, The Affiliated Guangdong Second Provincial General Hospital of Jinan University, Guangzhou 510317, China. Electronic address: hongxy8@mail2.sysu.edu.cn.
² Science and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou 510405, China. Electronic address: chentongkai@gzucm.edu.cn.
³ Key Laboratory of Human Microbiome and Chronic Diseases (Sun Yat-sen University), Ministry of Education, Guangzhou, China; Biomedical Innovation Center, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China; Department of Neurology, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China. Electronic address: liuyy46@mail.sysu.edu.cn.
⁴ Department of Alzheimer's Disease Clinical Research Center, The Affiliated Guangdong Second Provincial General Hospital of Jinan University, Guangzhou 510317, China. Electronic address: lijun_981010@163.com.
⁵ Department of Alzheimer's Disease Clinical Research Center, The Affiliated Guangdong Second Provincial General Hospital of Jinan University, Guangzhou 510317, China. Electronic address: 510698801@qq.com.
⁶ Department of Alzheimer's Disease Clinical Research Center, The Affiliated Guangdong Second Provincial General Hospital of Jinan University, Guangzhou 510317, China. Electronic address: 18676229886@163.com.
⁷ Department of Alzheimer's Disease Clinical Research Center, The Affiliated Guangdong Second Provincial General Hospital of Jinan University, Guangzhou 510317, China. Electronic address: 2200243071@email.szu.edu.cn.
⁸ Department of Alzheimer's Disease Clinical Research Center, The Affiliated Guangdong Second Provincial General Hospital of Jinan University, Guangzhou 510317, China. Electronic address: 1148560145@qq.com.
⁹ Department of Alzheimer's Disease Clinical Research Center, The Affiliated Guangdong Second Provincial General Hospital of Jinan University, Guangzhou 510317, China. Electronic address: 2300243047@email.szu.edu.cn.
¹⁰ Department of Alzheimer's Disease Clinical Research Center, The Affiliated Guangdong Second Provincial General Hospital of Jinan University, Guangzhou 510317, China; School of Basic Medical Sciences, Shenzhen University, Shenzhen 518060, China. Electronic address: luanping@szu.edu.cn.

PMID: 39864562
DOI: 10.1016/j.arr.2025.102669

Abstract

Alzheimer's disease (AD), an age-related neurodegenerative disease, brings huge damage to the society, to the whole family and even to the patient himself. However, until now, the etiological factor of AD is still unknown and there is no effective treatment for it. Massive deposition of amyloid-beta peptide(Aβ) and hyperphosphorylation of Tau proteins are acknowledged pathological features of AD. Recent studies have revealed that neuroinflammation plays a pivotal role in the pathology of AD. With the rise of nanomaterials in the biomedical field, researchers are exploring how the unique properties of these materials can be leveraged to develop effective treatments for AD. This article has summarized the influence of neuroinflammation in AD, the design of nanoplatforms, and the current research status and inadequacy of nanomaterials in improving neuroinflammation in AD.

Keywords: Alzheimer's disease; Blood-brain barrier; Nano drug delivery; Nanomaterials; Neuroinflammation.

Publication types

Review