Gold-Cerium bimetallic Star-Shaped nanoplatform for synergistic tumor therapy with nanozyme Catalytic/Photothermal/Chemotherapy

Chao Li; Zichao Guo; Wenqing Jia; Yan Kang; Meiling Zeng; Tingting Gu; Chaohui Zhou; Ren Zhao; Xi Cheng; Nengqin Jia

doi:10.1016/j.jcis.2025.01.157

Gold-Cerium bimetallic Star-Shaped nanoplatform for synergistic tumor therapy with nanozyme Catalytic/Photothermal/Chemotherapy

J Colloid Interface Sci. 2025 Jan 20:685:753-765. doi: 10.1016/j.jcis.2025.01.157. Online ahead of print.

Authors

Chao Li¹, Zichao Guo², Wenqing Jia², Yan Kang¹, Meiling Zeng¹, Tingting Gu¹, Chaohui Zhou¹, Ren Zhao³, Xi Cheng⁴, Nengqin Jia⁵

Affiliations

¹ The Education Ministry Key Lab of Resource Chemistry, Joint International Research Laboratory of Resource Chemistry, Ministry of Education, Shanghai Frontiers Science Center of Biomimetic Catalysis, and Shanghai Key Laboratory of Rare Earth Functional Materials, College of Chemistry and Materials Science, Shanghai Normal University, Shanghai 200234 China.
² Department of General Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025 China; Shanghai Institute of Digestive Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China 200025.
³ Department of General Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025 China; Shanghai Institute of Digestive Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China 200025. Electronic address: rjzhaoren@139.com.
⁴ Department of General Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025 China; Shanghai Institute of Digestive Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China 200025. Electronic address: drchengxi@126.com.
⁵ The Education Ministry Key Lab of Resource Chemistry, Joint International Research Laboratory of Resource Chemistry, Ministry of Education, Shanghai Frontiers Science Center of Biomimetic Catalysis, and Shanghai Key Laboratory of Rare Earth Functional Materials, College of Chemistry and Materials Science, Shanghai Normal University, Shanghai 200234 China. Electronic address: nqjia@shnu.edu.cn.

PMID: 39864385
DOI: 10.1016/j.jcis.2025.01.157

Abstract

A gold-cerium bimetallic asteroid nanoplatform (CeO₂@GNSs/Myr-HA) was obtained by electrostatically adsorbing ultra-small cerium dioxide (CeO₂) onto gold nanostars (GNSs) and further loading myricetin (Myr) and hyaluronic acid (HA). This nanoplatform exhibited three types of enzymatic properties-that is, GOD (glucose-oxidase), POD (peroxidase) and GSH-Ox (glutathione oxidase) mimicking catalytic activities. These enzymatic properties work together to effectively induce apoptosis in tumor cells. HA targets the CD44 receptor, which is located on the surface of tumor cells, leading to the further release of CeO₂@GNSs/Myr into the cytosol. Myr functions as a chemical agent that inhibits the expression of vascular endothelial growth factor (VEGF), thereby suppressing tumor cell angiogenesis via the p38/MAPK signaling pathway. When exposed to light radiation of 808-nm wavelength, the nanomaterials aggregated at the tumor site efficiently absorbed photons and converted them into thermal energy, enabling the precise thermal ablation of the malignancy. Moreover, CeO₂@GNSs/Myr-HA-as a multifunctional nanoplatform combining nanozyme catalytic therapy with photothermal therapy and chemotherapy-demonstrated the synergistic effect of effectively suppressing cancer cell proliferation and enhancing tumor ablation.

Keywords: Gold nanostar; Multi-enzyme mimetic activity; Multifunctional nanoplatform; Photothermal therapy; Synergistic therapy.