Study progress of etiologic mechanisms of chronic prostatitis/chronic pelvic pain syndrome

Xiyue Ma; Yongfeng Lao; Yanan Bai; Xin Guan; Jingyi Jiang; Minglu Cui; Zhilong Dong

doi:10.1016/j.intimp.2025.114128

Study progress of etiologic mechanisms of chronic prostatitis/chronic pelvic pain syndrome

Int Immunopharmacol. 2025 Jan 25:148:114128. doi: 10.1016/j.intimp.2025.114128. Online ahead of print.

Authors

Xiyue Ma¹, Yongfeng Lao², Yanan Bai³, Xin Guan², Jingyi Jiang², Minglu Cui², Zhilong Dong⁴

Affiliations

¹ The Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou, China.
² The Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou, China; Department of Urology, The Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou, China.
³ The Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou, China; Laboratory Medicine Center, The Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou, China.
⁴ The Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou, China; Department of Urology, The Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou, China. Electronic address: dzl19780829@163.com.

PMID: 39864227
DOI: 10.1016/j.intimp.2025.114128

Abstract

Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) represents a prevalent condition within the male genitourinary system. CP/CPPS occurs in men of varying ages, with an increasing recurrence rate associated with advancing age. The pathogenesis of CP/CPPS remains unclear, and clinical treatment typically focuses on symptom management with limited efficacy, resulting in significant economic and psychological burdens for patients. Research has increasingly identified several factors potentially associated with the development of CP/CPPS, including lifestyle, psychosocial influences, neuroendocrine elements, and other variables. This paper reviews recent studies on the risk factors and etiological mechanisms of CP/CPPS to enhance understanding of its mechanisms, providing a reference framework for future basic research and clinical diagnosis and treatment.

Keywords: Chronic prostatitis/chronic pelvic pain syndrome; Etiological mechanism; Prostatitis; Research progress; Review.

Publication types

Review