Prevalence and risk factors evaluation for transfusion-transmissible infections among blood donors from Shiyan, China

Yanqing Zhao; Shuguo Yang; Shengnan Wei; Peng Wu; Yuting Li; Daiqian Zhu; Wenhao Li; Yao Zhang; Wei Wang; Danmei Jiao; Jian Li

doi:10.1016/j.diagmicrobio.2025.116691

Prevalence and risk factors evaluation for transfusion-transmissible infections among blood donors from Shiyan, China

Diagn Microbiol Infect Dis. 2025 Jan 17;111(3):116691. doi: 10.1016/j.diagmicrobio.2025.116691. Online ahead of print.

Authors

Yanqing Zhao¹, Shuguo Yang¹, Shengnan Wei², Peng Wu¹, Yuting Li¹, Daiqian Zhu¹, Wenhao Li¹, Yao Zhang¹, Wei Wang³, Danmei Jiao⁴, Jian Li⁵

Affiliations

¹ Department of Human Parasitology, School of Basic Medical Science, Hubei University of Medicine, Shiyan, China.
² Shiyan Blood Transfusion Center, Laboratory Medical Center, Shiyan, China.
³ Jiangsu Institute of Parasitic Diseases, Wuxi, China.
⁴ Shiyan Blood Transfusion Center, Laboratory Medical Center, Shiyan, China. Electronic address: dmjiao@126.com.
⁵ Department of Human Parasitology, School of Basic Medical Science, Hubei University of Medicine, Shiyan, China. Electronic address: yxlijian@163.com.

PMID: 39862553
DOI: 10.1016/j.diagmicrobio.2025.116691

Abstract

Objective: Transfusion-transmissible infections (TTIs) are severe threats to blood safety and public health. A retrospective study of blood donor records from 2015 to 2019 in Shiyan, China, was conducted.

Methods: TTI prevalence was analyzed using ELISA, RT-PCR, and demographic data. Chi-square test and logistic regression were used to analyze incidence trends and associations for HIV, hepatitis B virus (HBV), hepatitis C virus (HCV), and Treponema pallidum (T. pallidum).

Results: Of 230,225 donors, 2,453 (1.07 %) were TTI-positive. HIV, HBV, HCV, syphilis rates were 0.08 %, 0.40 %, 0.19 %, 0.40 %. Significant decreases in HBV, HCV, T. pallidum from 2015 to 2019; HIV decreased from 2018 to 2019. The prevalence is higher among women aged 35-60, farmers with T. pallidum and young female students with HIV infection.

Conclusions: Despite the relatively low prevalence of TTIs at present, awareness of TTIs and ongoing blood screening are still needed to ensure blood safety.

Keywords: Blood donors; Hepatitis virus; Transfusion-transmissible infections; Treponema pallidum.