Derivation of induced pluripotent stem cell FDZSi002-A from a 67-year-old Chinese Han Prostate cancer patient

Chuan-Sheng Hou; Zhe Zhu; Xue-Feng Xie; Xue-Qiang Lu; Zhuo Chen; Hao-Yu Cui; Hao Wu; Bei Zhang; Chuan-Sheng Hou

doi:10.1016/j.scr.2025.103659

Derivation of induced pluripotent stem cell FDZSi002-A from a 67-year-old Chinese Han Prostate cancer patient

Stem Cell Res. 2025 Jan 7:83:103659. doi: 10.1016/j.scr.2025.103659. Online ahead of print.

Authors

Chuan-Sheng Hou¹, Zhe Zhu², Xue-Feng Xie¹, Xue-Qiang Lu¹, Zhuo Chen¹, Hao-Yu Cui¹, Hao Wu¹, Bei Zhang³, Chuan-Sheng Hou⁴

Affiliations

¹ Department of Urology, Jinshan Hospital of Fudan University, Shanghai, China.
² Shanghai Public Health Clinical Center Affiliated to Fudan University, 2901 Caolang Road, Jinshan, Shanghai 201508, China.
³ Department of Neurology, East Hospital, Tongji University School of Medicine, Shanghai, China. Electronic address: zhangbei0227@163.com.
⁴ Department of Urology, Jinshan Hospital of Fudan University, Shanghai, China. Electronic address: houchshaizb@163.com.

PMID: 39854878
DOI: 10.1016/j.scr.2025.103659

Abstract

Prostate cancer (PCa) is the most common malignant tumor of the male reproductive system. In this study, we generated an induced pluripotent stem cell (iPSC) line from the peripheral blood mononuclear cells (PBMCs) of a 67-year-old male patient and diagnosed with PC. The established iPSCs were confirmed by flow cytometry and immunofluorescence. Furthermore, the iPSC line has a normal chromosomal karyotype and has the potential of spontaneous differentiation into three germ layers in vitro. The iPSC line will be a useful tool for investigating the pathogenesis mechanisms of PCa.