Synthesis of chiral N-free sulfinamides by asymmetric condensation of stable sulfinates and ammonium salts

Chem Commun (Camb). 2025 Jan 24. doi: 10.1039/d4cc06395c. Online ahead of print.

Abstract

Herein, we developed a practical approach using stable, cost-effective ammonium salts with an organic base to generate anhydrous ammonia for asymmetric sulfinylation, achieving a broad range of enantioenriched sulfinamides with excellent yields and optical purity. Additionally, these sulfinamide products serve as versatile precursors for S-stereogenic functional molecules with potential in organic synthesis and drug discovery.