[Factors associated with venous thromboembolism in tuberculosis patients in Burkina Faso: A case control study]

Abstract

Introduction: The mortality caused by tuberculosis is partially explained by co-morbidities such as venous thromboembolic disease. Our study was aimed at identifying the factors associated with venous thromboembolism in tuberculosis patients.

Methods: This was a case-control study of patients with pulmonary tuberculosis with or without venous thromboembolic disease. The study was conducted in the pneumology department of Yalgado Ouédraogo University Hospital from 1st January 2021 to 31st March 2024.

Results: All in all, 80 patients were included in the study. In univariate analysis, the factors significantly associated with venous thromboembolic disease were: prolonged bed rest (P=0.000), hyperleukocytosis (P=0.044), hemoglobin level less than 10g/dL (P=0.024), C-reactive protein level greater than or equal to 150mg/L (P=0.036), bronchial dilatation lesions (P=0.041), and extensive lung lesions (P=0.016). After adjustment, prolonged bed rest (OR=7.68; [1.52-38.74]), hemoptysis (OR=24.65; [1.84-328.77]), leukocytosis (OR=2.13; [1.33-26.51]), were significantly associated with venous thromboembolism.

Conclusion: Venous thromboembolism remains a dreaded complication that should be investigated in any tuberculosis patient with thromboembolic risk factors.

Keywords: Burkina Faso; Case control study; Facteurs de risque; Maladie thromboembolique veineuse; Risk factors; Tuberculose; Tuberculosis; Venous thromboembolism; Étude cas-témoin.