Gut know-how: IL-22 from T cells boosts stress resilience

Ruodi Yang; Danyang He

doi:10.1016/j.immuni.2024.11.022

Gut know-how: IL-22 from T cells boosts stress resilience

Immunity. 2025 Jan 14;58(1):10-12. doi: 10.1016/j.immuni.2024.11.022.

Authors

Ruodi Yang¹, Danyang He²

Affiliations

¹ Laboratory of Neuroimmunology, School of Life Sciences, Hangzhou 310030, Zhejiang, China; Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou 310024, Zhejiang, China; School of Life Sciences, Fudan University, Shanghai 200438, China.
² Laboratory of Neuroimmunology, School of Life Sciences, Hangzhou 310030, Zhejiang, China; Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou 310024, Zhejiang, China. Electronic address: hedanyang@westlake.edu.cn.

PMID: 39813989
DOI: 10.1016/j.immuni.2024.11.022

Abstract

Immune activation during sustained stress typically worsens stress-related psychopathology. Whether it can enhance stress resilience remains unclear. In this issue of Immunity, Xia, Lu, Lan et al.¹ uncover an anxiolytic function of intestinal IL-22 pathway, which protects against psychological stress.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Animals
Humans
Interleukin-22*
Interleukins* / immunology
Interleukins* / metabolism
Intestines / immunology
Mice
Resilience, Psychological
Stress, Psychological* / immunology
T-Lymphocytes / immunology

Substances

Interleukin-22
Interleukins