Palladium-catalyzed allylic C-H alkylation of terminal olefins with 3-carboxamide oxindoles

Org Biomol Chem. 2025 Jan 15. doi: 10.1039/d4ob01991a. Online ahead of print.

Abstract

A novel palladium-catalyzed allylic C-H alkylation of terminal olefins with 3-carboxamide oxindoles is described. A variety of new 3-carboxamide-3-allylation oxindoles with an all-carbon quaternary center were obtained in moderate to good yields (up to 99%). In addition, the asymmetric version of this reaction was also explored, providing moderate enantioselectivity.