Green hydrothermal synthesis of nickel and zinc-doped nickel ferrite nanoparticles using Dalbergiella welwitschii extracts and their biological studies

Oghenejoboh Ufuoma Modupe; Sonibare Oluwadayo Olatunde; Muhammad Waseem; Ekundayo Olusegun; Sirajul Haq; Ahad Amer Alsaiari; Jamoliddin Razzokov

doi:10.1016/j.heliyon.2024.e40759

Green hydrothermal synthesis of nickel and zinc-doped nickel ferrite nanoparticles using Dalbergiella welwitschii extracts and their biological studies

Heliyon. 2024 Dec 6;11(1):e40759. doi: 10.1016/j.heliyon.2024.e40759. eCollection 2025 Jan 15.

Authors

Oghenejoboh Ufuoma Modupe¹, Sonibare Oluwadayo Olatunde¹, Muhammad Waseem², Ekundayo Olusegun¹, Sirajul Haq³, Ahad Amer Alsaiari³, Jamoliddin Razzokov^{4

5

6}

Affiliations

¹ Department of Chemistry, University of Ibadan, Ibadan, Nigeria.
² Department of Chemistry, COMSATS University Islamabad, Islamabad, Pakistan.
³ Department of Clinical Laboratory Science, College of Applied Medical Science, Taif University, Taif, Saudi Arabia.
⁴ Institute of Fundamental and Applied Research, National Research University TIIAME, Kori Niyoziy 39, 100000 Tashkent, Uzbekistan.
⁵ Department of Natural Sciences, Shakhrisabz State Pedagogical Institute, Shakhrisabz Street 10, Kashkadarya 181301, Uzbekistan.
⁶ Department of Biotechnology, Tashkent State Technical University, Universitet 2, Tashkent, 100095, Uzbekistan.

Abstract

Convectional drugs have failed to tackle the increasing public health challenge of Cancer and diabetes. Phytochemical conjugated nanoparticles are providing safer therapeutic alternatives to address this global challenge. Nanoparticles of nickel, iron and zinc are especially useful because of their magnetic properties, abilities to prevent the onset or slow the progression of these diseases. Nanoparticles of Ni/Fe and Ni/Fe/Zn were synthesized by hydrothermal reaction of Dalbergiella welwitschii extract with the respective metal chlorides, and were characterized using XRD, SEM, DLS, IR and UV- spectroscopy. The drug encapsulation and release profile of the ferrites was studied using curcumin as a test drug. the Anticancer and antidiabetic activities of the nanoparticles were investigated against MCF-7 breast cancer cell lines using the MTT assay and α-glucosidase enzyme inhibitory assay, respectively. The nanoparticles had high drug loading capacity (<10 %), promising cytotoxic activity against MCF-7 breast cancer cell lines and α-glucosidase inhibitory activities ranging between 5.6 and 13.4 μM comparable to standard drug acarbose (9.8 μM), respectively. Dalbergiella welwitschii mediated nanoparticles of Ni/Fe and Ni/Fe/Zn could be further explored as alternative therapeutic agents for cancer and diabetes.

Keywords: Anticancer; Antidiabetics; Dalbergiella welwitschii; Green synthesis; Nickel ferrite; Zinc doped nickel ferrite.