This paper presents a grid-based approach to model molecular association processes as an alternative to sampling-based Markov models. Our method discretizes the six-dimensional space of relative translation and orientation into grid cells. By discretizing the Fokker-Planck operator governing the system dynamics via the square-root approximation, we derive analytical expressions for the transition rate constants between grid cells. These expressions depend on geometric properties of the grid, such as the cell surface area and volume, which we provide. In addition, one needs only the molecular energy at the grid cell center, circumventing the need for extensive MD simulations and reducing the number of energy evaluations to the number of grid cells. The resulting rate matrix is closely related to the Markov state model transition matrix, offering insights into metastable states and association kinetics. We validate the accuracy of the model in identifying metastable states and binding mechanisms, though improvements are necessary to address limitations like ignoring bulk transitions and anisotropic rotational diffusion. The flexibility of this grid-based method makes it applicable to a variety of molecular systems and energy functions, including those derived from quantum mechanical calculations. The software package MolGri, which implements this approach, offers a systematic and computationally efficient tool for studying molecular association processes.