Association between the immune-inflammation indicators and osteoarthritis - NHANES 1999-2018

Yan Xue; Cheng Chang; Yajun Chen; Lang Jia; Han Wang; Zaoyang Liu; Jiang Xie

doi:10.1016/j.ocarto.2024.100453

Association between the immune-inflammation indicators and osteoarthritis - NHANES 1999-2018

Osteoarthr Cartil Open. 2024 Feb 29;7(1):100453. doi: 10.1016/j.ocarto.2024.100453. eCollection 2025 Mar.

Authors

Yan Xue^{1

2}, Cheng Chang^{3

2}, Yajun Chen^{1

4}, Lang Jia^{1

5}, Han Wang⁶, Zaoyang Liu³, Jiang Xie¹

Affiliations

¹ Department of Pediatrics, The Third People's Hospital of Chengdu, Affiliated Hospital of Southwest Jiaotong University & The Second Affiliated Hospital of Chengdu, Chongqing Medical University, Chengdu, Sichuan, China.
² Institute of Biomedical Engineering, College of Medicine, Southwest Jiaotong University, Chengdu 610031, Sichuan, China.
³ Department of Cardiothoracic Surgery, The Affiliated Hospital of Southwest Jiaotong University, The Third People's Hospital of Chengdu, Chengdu 610014, China.
⁴ North Sichuan Medical College, Nanchong 637100, China.
⁵ School of Clinical Medicine, Southwest Medical University, Luzhou, Sichuan 646000, China.
⁶ Department of Cardiology, The Affiliated Hospital of Southwest Jiaotong University, The Third People's Hospital of Chengdu, Chengdu 610014, China.

Abstract

Background: Investigate the link between systemic immune-inflammatory index (SII) and Systemic Immune Response Index (SIRI) with osteoarthritis (OA) using National Health and Nutrition Examination Survey (NHANES) data (1999-2018).

Methods: Extracted NHANES data (1999-2018) and selected a study population based on demographic, examination, and laboratory data. Calculated SII (platelet count × neutrophil count/lymphocyte count) and SIRI (neutrophil count × monocyte count/lymphocyte count). Employed multivariate logistic regression and restricted cubic spline (RCS) regression for Ln-SII, SIRI, and OA relationship investigation. Conducted subgroup analyses.

Results: Study involved 32,144 participants (16,515 males, 15,629 females), with 12.16% having OA. Positive correlation between highest SII quartile and OA in unadjusted and adjusted model 1 (Unadjusted Model, P < 0.001; Model 1, P = 0.01). In Model 2, adjusting for all factors, positive correlation observed, not statistically significant (Model 2, P = 0.07). Similar SIRI-OA correlation trends from Unadjusted Model to Model 2 (Unadjusted Model, P < 0.0001; Model 1, P < 0.0001; Model 2, P < 0.001). Subgroup analysis found no significant factors. Identified critical point at ln-SII ≈6.39 (SII = 595.86), beyond which OA prevalence significantly increased. No potential nonlinear SIRI-OA association (NL-P value > 0.05).

Conclusion: When SII exceeds 595.86, OA prevalence may rise. Besides, there was a significant positive correlation between SIRI and OA prevalence. SII and SIRI may be useful markers for OA research, warranting further exploration in this area.

Keywords: NHANES; Osteoarthritis; RCS; Systemic immune response index; Systemic immune-inflammation index; ln-SII.