A novel small-molecule fluorescent probe caused by minimal structural modifications for specific staining of the cell nuclear membrane

Chem Commun (Camb). 2025 Jan 13. doi: 10.1039/d4cc06678b. Online ahead of print.

Abstract

The nuclear membrane is a double-layered structure that physically protects the cell's DNA from the chemical reactions occurring in other parts of the cell. In this study, we present the first brand-new small-molecule fluorescent probe that selectively stains the nuclear membrane, allowing for the visualization of nuclear morphology without interfering with the DNA's activity.