Abstract
Proton pump inhibitors (PPIs), metabolized by cytochrome P450 (P450) enzymes, are widely used to inhibit gastric acid secretion. This study investigated CYP116B46, a self-sufficient monooxygenase with a reductase domain, to elucidate its interaction with ilaprazole, a PPI. Binding assays and docking simulations indicate that CYP116B46 serves as a suitable model for studying PPI metabolism.
MeSH terms
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2-Pyridinylmethylsulfinylbenzimidazoles / chemistry
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2-Pyridinylmethylsulfinylbenzimidazoles / metabolism
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Cytochrome P-450 Enzyme System* / chemistry
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Cytochrome P-450 Enzyme System* / metabolism
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Molecular Docking Simulation*
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Protein Binding
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Proton Pump Inhibitors / chemistry
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Proton Pump Inhibitors / metabolism
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Proton Pump Inhibitors / pharmacology
Substances
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Cytochrome P-450 Enzyme System
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ilaprazole
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Proton Pump Inhibitors
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2-Pyridinylmethylsulfinylbenzimidazoles