High-Throughput Hit Identification with Acoustic Ejection Mass Spectrometry

Xiujuan Wen; David G McLaren

doi:10.1016/j.slast.2025.100245

High-Throughput Hit Identification with Acoustic Ejection Mass Spectrometry

SLAS Technol. 2025 Jan 10:100245. doi: 10.1016/j.slast.2025.100245. Online ahead of print.

Authors

Xiujuan Wen¹, David G McLaren²

Affiliations

¹ Merck & Co., Inc., Rahway, NJ, USA. Electronic address: xiujuan.wen@merck.com.
² Merck & Co., Inc., Rahway, NJ, USA.

PMID: 39800101
DOI: 10.1016/j.slast.2025.100245

Abstract

This mini-review provides an overview of recent developments in AEMS supporting hit identification in drug discovery, emphasizing its potential to enhance the quality and efficiency of label-free HTS. Future advancements that may further expand the role of AEMS in the drug discovery process will also be discussed.

Keywords: Acoustic Ejection Mass Spectrometry; High-Throughput Screening; Hit Identification.

Publication types

Review