Real-world outcomes on myopia management efficacy of diverse segmented defocus optics (DSDO) and defocus incorporated multiple segments (DIMS) spectacle lenses in Chinese children: An initial 12-month prospective clinical study

Yuzhuo Fan; Huihui Chu; Zisu Peng; Jingwei Zhou; Jiahui Ma; Yuchang Lu; Chenxu Zhao; Yanyan Wang; Qiulin Deng; Jifeng Yu; Yan Li; Kai Wang; Mingwei Zhao

doi:10.1016/j.optom.2024.100533

Real-world outcomes on myopia management efficacy of diverse segmented defocus optics (DSDO) and defocus incorporated multiple segments (DIMS) spectacle lenses in Chinese children: An initial 12-month prospective clinical study

J Optom. 2025 Jan 11;18(1):100533. doi: 10.1016/j.optom.2024.100533. Online ahead of print.

Authors

Yuzhuo Fan¹, Huihui Chu², Zisu Peng¹, Jingwei Zhou¹, Jiahui Ma¹, Yuchang Lu¹, Chenxu Zhao¹, Yanyan Wang¹, Qiulin Deng¹, Jifeng Yu³, Yan Li⁴, Kai Wang⁵, Mingwei Zhao¹

Affiliations

¹ Department of Ophthalmology, Peking University People's Hospital, Beijing, China; Eye Diseases and Optometry Institute, Beijing, China; Beijing Key Laboratory of Diagnosis and Therapy of Retinal and Choroid Diseases, Beijing, China; College of Optometry, Peking University Health Science Center, Beijing, China.
² Department of Ophthalmology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China.
³ Department of Ophthalmology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China. Electronic address: jeffernyu@126.com.
⁴ Department of Ophthalmology, Peking University People's Hospital, Beijing, China; Eye Diseases and Optometry Institute, Beijing, China; Beijing Key Laboratory of Diagnosis and Therapy of Retinal and Choroid Diseases, Beijing, China; College of Optometry, Peking University Health Science Center, Beijing, China. Electronic address: 13801153660@163.com.
⁵ Department of Ophthalmology, Peking University People's Hospital, Beijing, China; Eye Diseases and Optometry Institute, Beijing, China; Beijing Key Laboratory of Diagnosis and Therapy of Retinal and Choroid Diseases, Beijing, China; College of Optometry, Peking University Health Science Center, Beijing, China. Electronic address: wang_kai@bjmu.edu.cn.

PMID: 39799796
DOI: 10.1016/j.optom.2024.100533

Abstract

Purposes: To investigate the 12-month effectiveness of Diverse Segmented Defocus Optics (DSDO) and Defocus Incorporated Multiple Segments (DIMS) spectacle lenses in a real-world clinical population in myopic and pre-myopic Chinese children.

Methods: About 364 subjects prescribed DSDO or DIMS were enrolled. Axial length (AL) and cycloplegic spherical equivalent refraction (SER) changes over 12 months were measured. The subjects were further divided into age sub-group (6-9; 10-14) and SER sub-group (+0.75D≤SER<-0.50D; -0.50D≤SER<-2.00D; -2.00D≤SER<-4.00D; SER≤-4.0D). Contrast sensitivity and visual experience were also reported. The rate of myopia progression was compared with historical single-vision spectacles (SVS) lenses data to evaluate the effectiveness of the regime.

Results: 317 subjects were analyzed. At 12-month, AL changes in the DSDO and DIMS group were 0.16±0.16 mm and 0.21±0.22 mm, respectively (P = 0.0202). DSDO spectacle lenses had better control effect in +0.75D≤SER<-0.50D and SER≤-2.0D sub-groups. The proportion of participants had no greater than 0.20 mm AL elongation was 65.00% and 55.41% of in DSDO and DIMS group separately. Myopia control effect in DSDO group was 47%-69% and 33%-62% in DIMS group compared to historical SVS lenses.

Conclusions: Both DSDO and DIMS spectacle lenses retarded AL elongation. DSDO showed more stable myopia control effect comparing to DIMS, especially in groups of SER≤-2.0D sub-groups and older patients. DSDO showed initial potential myopia prevention effect in pre-myopic children compared with historical SVS lenses data. However, the small sample and no control group in pre-myopes of this study are key limitations. Further research is needed to confirm and understand DSDO's role for pre-myopic children.

Keywords: DIMS; DSDO; Myopia; Optical defocus; Pre–myopia; Real–world.