The Role of Gli1+ Mesenchymal Stem Cells in Craniofacial Development and Disease Treatment

Wen Li; Han Jiang; Longshuang Hu; Tianjiao Shen; Qianming Chen

doi:10.1111/joor.13917

The Role of Gli1⁺ Mesenchymal Stem Cells in Craniofacial Development and Disease Treatment

J Oral Rehabil. 2025 Jan 10. doi: 10.1111/joor.13917. Online ahead of print.

Authors

Wen Li¹, Han Jiang¹, Longshuang Hu¹, Tianjiao Shen¹, Qianming Chen¹

Affiliation

¹ Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases of Zhejiang Province, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Engineering Research Center of Oral Biomaterials and Devices of Zhejiang Province, Hangzhou, China.

PMID: 39794930
DOI: 10.1111/joor.13917

Abstract

Objective: This review summarises the role of Gli1⁺ (Glioma-associated oncogene homologue 1) mesenchymal stem cells in craniofacial growth and development or tissue repair, and their application in the treatment of some diseases.

Design: The search for this narrative review was conducted in PubMed and Web of Science using relevant keywords, including checking reference lists of journal articles by hand searching.

Results: Gli1⁺ mesenchymal stem cells play an important role in the growth and development of the skull, tooth, periodontium and mandibular condyle. They can be applied to the treatment of pulp and periodontal diseases, temporomandibular joint osteoarthritis and other diseases.

Conclusions: Gli1⁺ mesenchymal stem cells are crucial for the development and repair of craniofacial tissue.

Keywords: Glioma‐associated oncogene homologue 1; condyle; craniofacial bone; mesenchymal stem cells; tooth.

Publication types

Review

Abstract

Publication types

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