Malignant brain tumor in early pregnancy mistaken for hyperemesis gravidarum

Taiwan J Obstet Gynecol. 2025 Jan;64(1):128-130. doi: 10.1016/j.tjog.2024.07.021.

Abstract

Objectives: The main objective of this case report is to discuss the differentiation between hyperemesis gravidarum and a brain tumor in the presence of hyperemesis symptoms in the first trimester of pregnancy.

Case report: A patient was initially diagnosed with hyperemesis gravidarum in early pregnancy and was hospitalized. After hospitalization, cerebral hemorrhage and cerebral hernia due to convulsions occurred. Magnetic resonance imaging showed a brain tumor. She underwent a craniotomy and then an artificial abortion. Despite treatment with radiation and chemotherapy, she died 9 months later.

Conclusion: Differentiating between hyperemesis gravidarum and a brain tumor based on a physical examination alone is difficult. Imaging should be performed when exacerbation of consciousness with suspected intracranial organic disease occurs.

Keywords: Brain tumor; First trimester; Glioblastoma; Hyperemesis gravidarum.

Publication types

  • Case Reports

MeSH terms

  • Abortion, Induced
  • Adult
  • Brain Neoplasms* / diagnosis
  • Craniotomy
  • Diagnosis, Differential
  • Diagnostic Errors
  • Fatal Outcome
  • Female
  • Humans
  • Hyperemesis Gravidarum* / complications
  • Hyperemesis Gravidarum* / diagnosis
  • Magnetic Resonance Imaging*
  • Pregnancy
  • Pregnancy Complications, Neoplastic / diagnosis
  • Pregnancy Trimester, First*