Drug Delivery in PROSE Device as Alternative to Frequent Drop Administration in Severe Ocular Surface Disease

Yandong Bian; Deborah S Jacobs

doi:10.1097/ICL.0000000000001163

Drug Delivery in PROSE Device as Alternative to Frequent Drop Administration in Severe Ocular Surface Disease

Eye Contact Lens. 2024 Dec 31. doi: 10.1097/ICL.0000000000001163. Online ahead of print.

Authors

Yandong Bian¹, Deborah S Jacobs

Affiliation

¹ Department of Ophthalmology, Massachusetts Eye & Ear, Harvard University, Boston, MA.

PMID: 39787424
DOI: 10.1097/ICL.0000000000001163

Abstract

The design of the prosthetic replacement of the ocular surface ecosystem (PROSE) device allows it to serve as a novel drug delivery system. In this article, we describe the off-label administration of amphotericin B and cenegermin by instillation in the PROSE device reservoir for the treatment of Candida keratitis in the setting of a persistent epithelial defect.