Rome IV functional defecation disorder: time for a change in symptom criteria for improved clinical relevance?

Calvin Joomann Park; Michael P Jones; Gillian Prott; Carol Sequeira; Allison Malcolm

doi:10.14309/ajg.0000000000003267

Rome IV functional defecation disorder: time for a change in symptom criteria for improved clinical relevance?

Am J Gastroenterol. 2024 Dec 30. doi: 10.14309/ajg.0000000000003267. Online ahead of print.

Authors

Calvin Joomann Park^{1

2}, Michael P Jones³, Gillian Prott², Carol Sequeira², Allison Malcolm^{1

2}

Affiliations

¹ Faculty of Medicine and Health, University of Sydney, Camperdown, NSW.
² Neurogastroenterology Unit and Department of Gastroenterology, Royal North Shore Hospital, St Leonards, NSW, Australia.
³ School of Psychological Sciences, Macquarie University, Sydney, Australia.

PMID: 39787361
DOI: 10.14309/ajg.0000000000003267

Abstract

Introduction: Defecatory disorders are common affecting up to 8% of the population. Rome IV diagnostic criteria are used to define this condition and therefore select patients for the gold standard therapy, anorectal biofeedback. The aim of this study was to test the current Rome IV FDD criteria in a real-world population by utilizing the response to biofeedback as a validation tool.

Methods: 485 patients (F 437 mean age 50±17.6) with defecatory symptoms presenting to a Neurogastroenterology clinic underwent anorectal biofeedback therapy regardless of whether they met formal Rome IV FDD criteria or not. Patients were assessed extensively with Rome questionnaire, constipation questionnaire and visual analog scales for satisfaction, control and quality of life and anorectal manometry.

Results: Rome IV FDD was no better at predicting response to biofeedback compared to non-Rome IV FDD (p=NS). Digitation (p=0.043) and increasing cumulative number of defecatory symptoms (p=0.038) were correlated with improvement with biofeedback (≥2 point increase in bowel satisfaction). Those with abnormal physiology only responded well to biofeedback (83% response rate) but this was not statistically different to non-physiology patients (73%). There was a trend for increasing cumulative number of abnormal physiology factors to correlate with biofeedback (p=0.086).

Discussion: Rome IV symptom criteria need revision to include more defecatory symptoms, include all subtypes of IBS, and be inclusive of those with either loose stools or more frequent stools such as those previously labelled with "pseudodiarrhea" or "hyperdefecation". Continuing to include physiology criteria in the Rome diagnosis of FDD appears valid.