Cosmetic procedures carry inherent risks of adverse events. Though rarely reported, transient and permanent alopecia are potential complications of these procedures. We report the case of a 35-year-old woman who developed pain and patches of nonscarring alopecia with erythema and edema following aesthetic application of poly-L-lactic acid (PLLA) on the face and along the frontal hairline. Trichoscopy and histopathologic analysis confirmed the diagnosis. Dermatologists should be aware of the potential for embolization and retinal ischemia following the use of PLLA. Moreover, trichoscopy combined with histopathologic analysis should be encouraged to improve early recognition and proper management of this rare adverse event.