Intranodular Thyroid Metastasis of a Large Cell Neuroendocrine Carcinoma of the Endometrium

Capucine Richard; Abir Al Ghuzlan; Virginie Huchet; Vincent Cockenpot; Ségolène Hescot

doi:10.1097/RLU.0000000000005665

Intranodular Thyroid Metastasis of a Large Cell Neuroendocrine Carcinoma of the Endometrium

Clin Nucl Med. 2025 Jan 9. doi: 10.1097/RLU.0000000000005665. Online ahead of print.

Authors

Capucine Richard¹, Abir Al Ghuzlan², Virginie Huchet³, Vincent Cockenpot⁴, Ségolène Hescot¹

Affiliations

¹ From the Institut Curie, Department of Nuclear Medicine, Saint-Cloud.
² Institut Gustave Roussy, Cancer Medical Pathology and Biology Department, Villejuif.
³ Departments of Nuclear Medicine.
⁴ Pathology, Institut Curie, Paris, France.

PMID: 39780362
DOI: 10.1097/RLU.0000000000005665

Abstract

A 64-year-old woman underwent initial 18F-FDG PET/CT staging for a suspicious endometrial mass, which showed high uptake in the endometrial mass and a focal uptake in a known left thyroid nodule. Histology revealed a high-grade large cell neuroendocrine carcinoma of the endometrium with FIGO (International Federation of Gynecology and Obstetrics) stage Ib. Further explorations revealed a synchronous thyroid metastasis. Patient then received adjuvant immunochemotherapy. This case showed a potential pitfall in the initial assessment of this rare and aggressive malignancy on which the therapeutic approach greatly depends.