Gut Neuropathies and Intestinal Motility Disorders

David A Wattchow; Simon J H Brookes; Nick J Spencer; Roberto De Giorgio; Marcello Costa; Phil G Dinning

doi:10.1111/nmo.14995

Gut Neuropathies and Intestinal Motility Disorders

Neurogastroenterol Motil. 2025 Jan 8:e14995. doi: 10.1111/nmo.14995. Online ahead of print.

Authors

David A Wattchow^{1

2

3}, Simon J H Brookes¹, Nick J Spencer¹, Roberto De Giorgio⁴, Marcello Costa¹, Phil G Dinning^{1

2

3}

Affiliations

¹ College of Medicine and Public Health, Flinders University, Adelaide, South Australia, Australia.
² Department of Surgery, Flinders Medical Centre, Adelaide, South Australia, Australia.
³ Department of Gastroenterology, Flinders Medical Centre, Adelaide, South Australia, Australia.
⁴ Department of Translational Medicine, University of Ferrara, Ferrara, Italy.

PMID: 39777822
DOI: 10.1111/nmo.14995

Abstract

Background: The enteric nervous system plays a key role in the coordination of gastrointestinal motility together with sympathetic, parasympathetic, and extrinsic sensory pathways. In some cases, abnormalities in neural activity in these pathways contribute to disorders of gut motility. Where this is associated with damage or death of enteric neurons, usually detected by microscopy, this is considered a gut neuropathy.

Purpose: This review summarizes recent advances in the identification of neuropathies in a range of gastrointestinal motility disorders.

Keywords: diagnotic; digestive tract; nerve; neuropathy.

Publication types

Review