Physical activity (PA) is beneficial for several health outcomes. Adults born with very low birth weight (VLBW<1500g) undertake less PA than those born at term, have poorer motor abilities and may serve as a model on early life origins of PA. We therefore examined whether motor abilities mediate the association between being born with VLBW and device-measured PA. In a joint assessment of two longitudinal birth cohorts from Finland and Norway, PA was measured by two tri-axial accelerometers in 87 adults born preterm with VLBW and 109 controls born at term. We explored the mediating role of motor abilities assessed by standardized tests on the association between VLBW and device-measured PA. To do this, we examined group differences in metabolic equivalent of task (MET) min/day of moderate to vigorous PA (MVPA), light PA and sedentary. Analyses were adjusted for cohort, age and sex. MVPA was 40.4 (95% confidence interval [CI]: 13.3 to 69.4) MET min/day lower in the VLBW group than the control group. This was in part mediated through gross motor abilities, indicated by the indirect effect on the association between VLBW and MVPA being -15.6 (95% CI: -28.5 to -5.4) MET min/day. In conclusion, adults born preterm with VLBW undertake less MVPA than controls born at term, and gross motor abilities mediate this association. Interventions targeting motor abilities should be examined as potential ways to increase PA.
Copyright: © 2025 Benum et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.