EWSR1::BEND2 Adenocarcinoma with Hyaline Pseudorosettes of the Trachea

Head Neck Pathol. 2025 Jan 7;19(1):7. doi: 10.1007/s12105-024-01746-y.

Abstract

We describe the novel occurrence of a adenocarcinoma involving the trachea, with distinct solid and glandular components, in a 34-year-old patient. We illustrate its morphological and immunophenotypic features and describe the molecular finding of an EWSR1::BEND2 gene fusion detected by next-generation sequencing (NGS). We discuss the findings in comparison to BEND2-fusion associated neoplasms reported in the head and neck region in the literature to date.

Keywords: BEN domain proteins; BEND2; ESWR1::BEND2 Fusion; Gene fusion; Salivary gland carcinoma.

Publication types

  • Case Reports

MeSH terms

  • Adenocarcinoma* / genetics
  • Adenocarcinoma* / pathology
  • Adult
  • Biomarkers, Tumor / genetics
  • Humans
  • Male
  • Oncogene Proteins, Fusion / genetics
  • RNA-Binding Protein EWS* / genetics
  • Tracheal Neoplasms* / genetics
  • Tracheal Neoplasms* / pathology

Substances

  • EWSR1 protein, human
  • RNA-Binding Protein EWS
  • Oncogene Proteins, Fusion
  • Biomarkers, Tumor