Multifunctional hydrogel scaffolds based on polysaccharides and polymer matrices promote bone repair: A review

Abstract

With the advancement of medical technology, the utilization of bioactive materials to promote bone repair has emerged as a significant research area. Hydrogels, as biomaterials, play a crucial role in bone tissue engineering. These hydrogels exhibit high biocompatibility, providing in vivo ecological conditions conducive to cell survival, and offer substantial advantages in facilitating bone repair. Different matrices of hydrogels serve distinct functions. In recent years, numerous researchers have developed a variety of novel hydrogel materials utilizing diverse matrices. These materials not only enhance the osteogenic induction capacity of hydrogels but also improve their efficacy as scaffolds in the treatment of complex bone defects, such as those resulting from trauma, tumor resection, or large bone defects due to infection. This article primarily analyzes the role of hydrogels that utilize polysaccharides and polymers as matrices in bone tissue repair, focusing on the creation of an optimal microenvironment to promote bone regeneration. These investigations deepen the understanding of the mechanisms underlying the action of hydrogels and establish a foundation for future advancements in the biomedical field.

Keywords: Bone defects; Bone repair; Bone tissue engineering; Hydrogel.