A "cyclodextrin-salicylic acid-chitosan" bifunctional monomer magnetic hydrophilic imprinted sandwich gel for targeted adsorption and slow release of ginkgolic acid

Xiaodan Wu; Guansong Shao; Zihan Wang; Bingyang Qin; Tao Wang; Ying Wang; Yujie Fu

doi:10.1016/j.ijbiomac.2024.139410

A "cyclodextrin-salicylic acid-chitosan" bifunctional monomer magnetic hydrophilic imprinted sandwich gel for targeted adsorption and slow release of ginkgolic acid

Int J Biol Macromol. 2025 Jan 5:139410. doi: 10.1016/j.ijbiomac.2024.139410. Online ahead of print.

Authors

Xiaodan Wu¹, Guansong Shao¹, Zihan Wang¹, Bingyang Qin¹, Tao Wang¹, Ying Wang¹, Yujie Fu²

Affiliations

¹ Key Laboratory of Forest Plant Ecology, Ministry of Education, Northeast Forestry University, 150040 Harbin, PR China; Engineering Research Center of Forest Bio-preparation, Ministry of Education, Northeast Forestry University, Harbin 150040, China; The College of Chemistry, Chemical Engineering and Resource Utilization, Northeast Forestry University, 150040 Harbin, PR China.
² The College of Forestry, Beijing Forestry University, 100083, Beijing, PR China. Electronic address: yujie_fu@163.com.

PMID: 39765294
DOI: 10.1016/j.ijbiomac.2024.139410

Abstract

This study aims to address the challenge of detoxifying ginkgolic acid and transform it from waste into a valuable resource. By using pseudo-template molecular imprinting technology to chemically modify polysaccharide materials, we developed a polysaccharide-based molecular imprinted material (MMCC-CD/CS-MIP) for the targeted separation and controlled release of ginkgolic acid. Under optimal conditions, MMCC-CD/CS-MIP demonstrated excellent adsorption performance (Q_max = 47.786 mg g^-1) and desorption performance (Q_D = 42.33 mg g^-1), with a desorption rate of 88.58 %. In addition, the material exhibited outstanding selectivity, stability, recyclability, antibacterial activity, and sustained-release properties, with a cumulative release rate of 95.57 % over 72 h. The release data followed the Korsmeyer-Peppas model, while the adsorption behavior fit a multi-layer heterogeneous adsorption model (Freundlich model) and conformed to a second-order kinetic model. Thermodynamic analysis confirmed that the adsorption of ginkgolic acid by MMCC-CD/CS-MIP is both feasible and spontaneous. MMCC-CD/CS-MIP provides a promising solution for the detoxification of medicinal components.

Keywords: Composite natural polysaccharide; Detoxification; Ginkgolic acids; Molecular imprinting technology; Resource reuse.