Sarcopenia as a Prognostic Factor and Multimodal Interventions in Breast Cancer

Ludi Du; Xiang Liu; Qiaoli Zhu; Kuangye Zhu; Ping Li

doi:10.2147/IJGM.S497897

Sarcopenia as a Prognostic Factor and Multimodal Interventions in Breast Cancer

Int J Gen Med. 2024 Dec 31:17:6605-6616. doi: 10.2147/IJGM.S497897. eCollection 2024.

Authors

Ludi Du¹, Xiang Liu¹, Qiaoli Zhu¹, Kuangye Zhu¹, Ping Li¹

Affiliation

¹ Department of Thyroid and Breast Surgery, Quzhou People's Hospital, Quzhou, 324000, People's Republic of China.

Abstract

Objective: This study aims to demonstrate the impact of sarcopenia on the prognosis of early breast cancer and its role in early multimodal intervention.

Methods: The clinical data of patients (n=285) subjected to chemotherapy for early-stage breast cancer diagnosed pathologically between January 1, 2016, and December 31, 2020, in our hospital were retrospectively analyzed. Accordingly, the recruited subjects were divided into sarcopenia (n=85) and non-sarcopenia (n=200) groups according to CT diagnosis correlating with single-factor and multifactorial logistic regression analyses. Further, the breast cancer patients combined with sarcopenia were randomly divided into multimodal, nutritional, exercise, and control intervention groups. Multimodal interventions combined supervised exercise programs and tailored nutritional support. The preliminary data and post-operative efficacy, as well as post-operative survival of patients of the four groups, were compared.

Results: Sarcopenia significantly reduced overall survival (OS) rates at 1 year (82.94% vs 85.78%), 3 years (81.76% vs 83.91%), and 5 years (80.59% vs 81.17%) compared to non-sarcopenia patients (P<0.001). Patients in the multimodal intervention group showed better outcomes, including improved ALB levels, reduced complication rates (4.5% vs 18.18% vs 18.18% vs.52.63%), and fewer chemotherapy side effects. The multifactorial stepwise logistic regression analysis indicated that advanced age (OR: 1.512, 95% CI: 1.178-1.962, P < 0.001) and multimodal intervention pathways (OR: 5.333, 95% CI: 2.651-10.473, P < 0.001) were significant risk factors affecting patients'prognosis.

Conclusion: Sarcopenia might be an independent risk factor leading to the increase of post-operative complications and the shortening of long-term survival of patients. Moreover, the multimodal intervention of nutrition combined with exercise could effectively improve the quality of the prognosis of patients with important clinical significance.

Keywords: early breast cancer; influencing factors; multimodal interventions; prognosis; sarcopenia.

Grants and funding

The study was funded by the effect of sarcopenia on prognosis of early breast cancer and the role of early multi-mode intervention (Quzhou Science and Technology Bureau 2021Y007).