Decoding the protein methylome: Identification, validation, and functional insights

Ying Meng; Rong Huang

doi:10.1016/j.bmc.2024.118056

Decoding the protein methylome: Identification, validation, and functional insights

Bioorg Med Chem. 2024 Dec 28:118:118056. doi: 10.1016/j.bmc.2024.118056. Online ahead of print.

Authors

Ying Meng¹, Rong Huang²

Affiliations

¹ Borch Department of Medicinal Chemistry and Molecular Pharmacology, Purdue Institute for Drug Discovery, Purdue University Center for Cancer Research, Purdue University, West Lafayette, IN 47907, United States.
² Borch Department of Medicinal Chemistry and Molecular Pharmacology, Purdue Institute for Drug Discovery, Purdue University Center for Cancer Research, Purdue University, West Lafayette, IN 47907, United States. Electronic address: huang-r@purdue.edu.

PMID: 39754853
DOI: 10.1016/j.bmc.2024.118056

Abstract

Protein methylation regulates diverse cellular processes including gene expression and DNA repair. This review discusses the methods of identifying and validating substrates for protein methyltransferases (MTases), as well as the biological roles of methylation. Meanwhile, we outline continued efforts necessary to fully map MTase-substrate pairs and uncover the complex regulatory roles of protein methylation in cellular function.

Keywords: Function; Methylome; Methyltransferase; Substrate Identification; Validation.

Publication types

Review