Decoding Epilepsy: Prickle2 and Multifaceted Molecular Pathway Connections

Yuhang Liu; Fan Peng; Jie Shu; Xiaolan Li; Chengfu Yuan

doi:10.2174/0113816128333500241031100623

Decoding Epilepsy: Prickle2 and Multifaceted Molecular Pathway Connections

Curr Pharm Des. 2025 Jan 1. doi: 10.2174/0113816128333500241031100623. Online ahead of print.

Authors

Yuhang Liu^{1

2

3}, Fan Peng^{1

2

3}, Jie Shu¹, Xiaolan Li^{4

5}, Chengfu Yuan^{1

2

3}

Affiliations

¹ Hubei Key Laboratory of Tumor Microenvironment and Immunotherapy, China Three Gorges University, Yichang, Hubei, China.
² College of Basic Medical Science, China Three Gorges University, Yichang 443002, China.
³ Third-grade Pharmacological Laboratory on Traditional Chinese Medicine, State Administration of Traditional Chinese Medicine, China Three Gorges University, Yichang, Hubei, China.
⁴ The Second People's Hospital of China Three Gorges University, Yichang, Hubei, China.
⁵ The Second People's Hospital of Yichang, Hubei, China.

PMID: 39754765
DOI: 10.2174/0113816128333500241031100623

Abstract

Background: The Prickle2 (Pk2) gene shows promising potential in uncovering the underlying causes of epilepsy, a neurological disorder that is currently not well understood. This paper utilizes the online tool PubMed to gather and condense information on the involvement of PCP channels and the associated roles of PCP pathway molecules in the onset of epilepsy. These findings are significant for advancing epilepsy treatment. Additionally, the paper discusses future directions for clinical trials and outlines potential therapeutic targets.

Methods: This review systematically analyzes the biological functions and mechanisms of the Prickle2 gene in epilepsy. Studies were retrieved from PubMed using keywords such as "Prickle2," "epilepsy," and "PCP pathway," focusing on research published between 2000 and 2023 in English. Inclusion criteria included original studies and reviews on Prickle2's role in epilepsy. Studies unrelated to these topics or lacking sufficient data were excluded. Key data on Prickle2's functions and its link to epilepsy were extracted, and findings were summarized after a quality assessment of the literature.

Results: Although there are currently conflicting results regarding the possibility that Prickle2 may cause epilepsy in different organisms, we believe that as more cases involving Prickle2 mutations are reported and more related animal experiments are conducted, the findings will become clearer.

Conclusion: Due to the biological functions and mechanisms associated with the Prickle2 protein, it may serve as a useful biomarker or potential therapeutic target for epilepsy treatment.

Keywords: AIS; AnkG; FMRP; NGS; PCP; Prickle2; USP9X; Wnt5a; epilepsy; protein interactions..