A cutting-edge investigation of the multifaceted role of SOX family genes in cancer pathogenesis through the modulation of various signaling pathways

Saade Abdalkareem Jasim; Shireen Hamid Farhan; Irfan Ahmad; Ahmed Hjazi; Ashwani Kumar; Mohammed Abed Jawad; Atreyi Pramanik; M A Farag Altalbawy; Salim B Alsaadi; Munther Kadhim Abosaoda

doi:10.1007/s10142-024-01517-6

A cutting-edge investigation of the multifaceted role of SOX family genes in cancer pathogenesis through the modulation of various signaling pathways

Funct Integr Genomics. 2025 Jan 4;25(1):6. doi: 10.1007/s10142-024-01517-6.

Authors

Affiliations

¹ Medical Laboratory Techniques Department, College of Health and Medical Technology, University of Al-maarif, Anbar, Iraq. Saadeek.jasim@hotmail.com.
² Biology Department, College of Education, Fallujah University, Fallujah, Iraq.
³ Department of Clinical Laboratory Sciences, College of Applied Medical Science, King Khalid University, Abha, Saudi Arabia.
⁴ Department of Medical Laboratory, College of Applied Medical Sciences, Prince Sattam bin Abdulaziz University, Al-Kharj, 11942, Saudi Arabia.
⁵ Department of Life Sciences, School of Sciences, Jain (Deemed-to-be) University, Bengaluru, Karnataka, 560069, India.
⁶ Department of Pharmacy, Vivekananda Global University, Jaipur, Rajasthan, 303012, India.
⁷ Department of Pharmaceutics, Al-Nisour University College, Baghdad, Iraq.
⁸ School of Applied and Life Sciences, Division of Research and Innovation, Uttaranchal University, Dehradun, Uttarakhand, India.
⁹ Department of Chemistry, University College of Duba, University of Tabuk, Tabuk, Saudi Arabia.
¹⁰ Department of Pharmaceutics, Al-Hadi University College, Baghdad, 10011, Iraq.
¹¹ College of Pharmacy, The Islamic University, Najaf, Iraq.
¹² College of Pharmacy, The Islamic University of Al Diwaniyah, Al Diwaniyah, Iraq.
¹³ College of Pharmacy, The Islamic University of Babylon, Al Diwaniyah, Iraq.

PMID: 39753912
DOI: 10.1007/s10142-024-01517-6

Abstract

This detailed study examines the complex role of the SOX family in various tumorigenic contexts, offering insights into how these transcription factors function in cancer. As the study progresses, it explores the specific contributions of each SOX family member. The significant roles of the SOX family in the oncogenic environment are well-recognized, highlighting a range of regulatory mechanisms that influence tumor progression. In brain, lung, and colorectal cancers, SOX types like SOX2, SOX3, and SOX4 promote the migration, proliferation, and angiogenesis of cancer cells. Conversely, in pancreatic, gastric, and breast cancers, SOX types, including SOX1, SOX9, and SOX17 inhibit various cancer cell activities such as proliferation and invasion. This thorough investigation enhances our understanding of the SOX family's complex role in cancer, establishing a foundation for future research and potential therapeutic strategies targeting these versatile transcription factors.

Keywords: Cancer; Oncogenic; SOX proteins; Tumor-suppressor.

Publication types

Review

Grants and funding

R.G.P.1/323/44/Deanship of Scientific Research, King Khalid University