Significant Association Between Genetic Polymorphism of Insulin-Like Growth Factor-2 mRNA Binding Protein-2 and Type 2 Diabetes Mellitus: A Population-Based Case-Control Study

Elmutuz H Elssaig; Eltayib H Ahmed-Abakur; Tarig M S Alnour; Mohammed A Alsubai; Abdalla Eltoum Ali; Mohammad Fahad Ullah; Nizar H Saeedi; Fahad Daefalah Alenzi

doi:10.1002/jcla.25147

Significant Association Between Genetic Polymorphism of Insulin-Like Growth Factor-2 mRNA Binding Protein-2 and Type 2 Diabetes Mellitus: A Population-Based Case-Control Study

J Clin Lab Anal. 2025 Jan 3:e25147. doi: 10.1002/jcla.25147. Online ahead of print.

Authors

Elmutuz H Elssaig^{1

2

3}, Eltayib H Ahmed-Abakur^{1

2

4}, Tarig M S Alnour^{1

2

4}, Mohammed A Alsubai^{1

2

3}, Abdalla Eltoum Ali³, Mohammad Fahad Ullah¹, Nizar H Saeedi¹, Fahad Daefalah Alenzi⁵

Affiliations

¹ Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, University of Tabuk, Tabuk, Saudi Arabia.
² Prince Fahad Bin Sultan Chair for Biomedical Research, University of Tabuk, Tabuk, Saudi Arabia.
³ Faculty of Medical Laboratory Science, Department of Clinical Chemistry Alzaiem Alazhari University, Khartoum North, Sudan.
⁴ Faculty of Medical Laboratory Science, Department of Microbiology and Immunology Alzaiem Alazhari University, Khartoum North, Sudan.
⁵ Medical Laboratory Specialist- Clinical Chemistry Lab -King Fahd Specialist Hospital, Tabuk, Kingdom of Saudi Arabia, Saudi Arabia.

PMID: 39749895
DOI: 10.1002/jcla.25147

Abstract

Objectives: To determine the association between IGF2BP2 polymorphisms and type 2 diabetes mellitus.

Methods: This study involved 422 individuals, 214 diabetes mellitus cases, and 208 healthy controls. The PCR-RFLP technique was used to determine the genotype of the IGF2BP2 gene for the SNPs rs4402960 (G>T) and rs1470579 (A>C).

Results: The results showed that the C allele of the rs1470579 variant and the T allele of the rs440960 variant were significantly associated with type 2 diabetes mellitus group (p = 0.0029 and 0.0001) as reported for both alleles, respectively. High frequencies of haplotypes TA and TC were observed in type 2 diabetes patients.

Conclusion: The present study showed that IGF2BP2 rs1470579 and rs4402960 polymorphism were significantly associated with the increased risk of T2DM in the Saudi Arabian population and presented a genetic model to screen the high-risk individuals with further validations.

Keywords: BMI; IGF2BP2; SNPs; T2DM; genetic variants; genomic markers.

Grants and funding

S-0115-1439/Deanship of Scientific Research (DSR), University of Tabuk, Kingdom of Saudi Arabia