Ancient structural variants control sex-specific flowering time morphs in walnuts and hickories

Science. 2025 Jan 3;387(6729):eado5578. doi: 10.1126/science.ado5578. Epub 2025 Jan 3.

Abstract

Balanced mating type polymorphisms offer a distinct window into the forces shaping sexual reproduction strategies. Multiple hermaphroditic genera in Juglandaceae, including walnuts (Juglans) and hickories (Carya), show a 1:1 genetic dimorphism for male versus female flowering order (heterodichogamy). We map two distinct Mendelian inheritance mechanisms to ancient (>37 million years old) genus-wide structural DNA polymorphisms. The dominant haplotype for female-first flowering in Juglans contains tandem repeats of the 3' untranslated region of a gene putatively involved in trehalose-6-phosphate metabolism and is associated with increased cis gene expression in developing male flowers, possibly mediated by small RNAs. The Carya locus contains ~20 syntenic genes and shows molecular signatures of sex chromosome-like evolution. Inheritance mechanisms for heterodichogamy are deeply conserved, yet may occasionally turn over, as in sex determination.

Publication types

  • Review

MeSH terms

  • 3' Untranslated Regions
  • Carya* / anatomy & histology
  • Carya* / genetics
  • Carya* / growth & development
  • Evolution, Molecular
  • Flowers* / genetics
  • Flowers* / growth & development
  • Gene Expression Regulation, Plant
  • Haplotypes*
  • Juglans* / anatomy & histology
  • Juglans* / genetics
  • Juglans* / growth & development
  • Polymorphism, Genetic
  • Reproduction / genetics
  • Sex Chromosomes / genetics
  • Synteny
  • Tandem Repeat Sequences

Substances

  • 3' Untranslated Regions