Photoinduced synthesis of trisubstituted allylic molecules via migratory allylation of olefins

Chem Commun (Camb). 2025 Jan 2. doi: 10.1039/d4cc05368k. Online ahead of print.

Abstract

A transition-metal-free method to afford diverse trisubstituted allylic molecules via migratory allylation of olefins under light irradiation is described. This system tolerated diverse N-tosylhydrazones and olefinic boronic acids. Successful allylation of drugs and natural-product analogues was achieved. The gram-scale synthesis and subsequent post-transformation demonstrated the potential applications of this strategy.