Discrimination of nucleoside phosphates using principal component analysis of spectral changes in a single europium complex

Leila R Hill; Elizabeth J New; Stephen Faulkner

doi:10.1039/d4cc05815a

Discrimination of nucleoside phosphates using principal component analysis of spectral changes in a single europium complex

Chem Commun (Camb). 2025 Jan 2. doi: 10.1039/d4cc05815a. Online ahead of print.

Authors

Leila R Hill^{1

2

3}, Elizabeth J New^{2

3

4}, Stephen Faulkner¹

Affiliations

¹ Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford, UK. leila.hill@sydney.edu.au.
² School of Chemistry, The University of Sydney, Sydney, NSW, 2006, Australia.
³ Australian Research Council Centre of Excellence for Innovations in Peptide and Protein Science, The University of Sydney, Sydney, NSW, 2006, Australia.
⁴ Sydney Nano Institute, The University of Sydney, Sydney, NSW, 2006, Australia.

PMID: 39744841
DOI: 10.1039/d4cc05815a

Abstract

Here we present the first use of principal component analysis of the full spectrum of a single europium complex to differentiate between structurally-similar analytes. We demonstrate that it can be used to distinguish between the nucleoside phosphate guests AMP, ADP, and ATP.