Tooth development is a complex biomineralization process formed through the interaction between epithelial tissue and mesenchymal tissue. The Ca2+ transport channel is the intrinsic regulatory mechanism of this process, which regulates the concentration of Ca2+ inside and outside the cell in time and space, thereby affecting the biological functions of various cells and the growth of extracellular hydroxyapatite. This article reviews the researches on the effects of Ca2+ transport in tooth biomineralization and corresponding cell development in recent years, with the aim of providing ideas and basis for the prevention of tooth developmental defects, assisting in early clinical diagnosis, and improving treatment methods.
牙齿发育通过上皮组织和间充质组织之间相互作用而形成，是一个复杂的生物矿化过程。Ca2+转运通道是这一过程的内在调节机制，在时间和空间上调节细胞内外Ca2+的浓度，进而影响多种细胞的生物学功能以及细胞外羟基磷灰石的生长。本文就近年来Ca2+转运对牙齿生物矿化及相应细胞发育影响的研究进行综述，以期为牙发育缺陷的预防、辅助临床早期诊断和改进治疗手段提供思路和依据。.