Single-cell and spatial multi-omics technologies enable the simultaneous analysis of thousands of cells in various states, revealing their transcriptional profiles, chromatin accessibility, and spatial positioning. Recent advances in single-cell multi-omics have led to significant discoveries regarding the definition, function, evolution, and interaction of various cell subtypes during tooth development. We summarize key findings from recent single-cell multi-omics studies on tooth development, highlighting their contributions to the field and discussing future perspectives in dental developmental genomics research.
单细胞结合空间多组学技术可以对不同状态下组织器官成千上万的细胞同时进行转录组、染色质开放状态等信息进行解析，并描述其空间定位。近年来，得益于单细胞多组学技术的发展，牙发育过程中各细胞亚型的定义、功能、演化和相互作用取得了许多重要进展。本文对已经发表的几篇牙发育单细胞多组学文章进行总结介绍，阐明单细胞多组学在推动牙发育研究中的作用，并对未来牙发育组学的研究前景进行展望。.