Exploring the Prognostic Role of Red Blood Cell Distribution Width in Aortic Valve Calcification Evaluations via Multi-Slice Computed Tomography

Yiyao Zeng; Fulu Jin; Li Wang; Peiyu Wang; Hui Xiong; Yafeng Zhou; Yufeng Jiang; Liangping Zhao

doi:10.31083/j.rcm2512437

Exploring the Prognostic Role of Red Blood Cell Distribution Width in Aortic Valve Calcification Evaluations via Multi-Slice Computed Tomography

Rev Cardiovasc Med. 2024 Dec 12;25(12):437. doi: 10.31083/j.rcm2512437. eCollection 2024 Dec.

Authors

Yiyao Zeng¹, Fulu Jin², Li Wang³, Peiyu Wang², Hui Xiong³, Yafeng Zhou¹, Yufeng Jiang¹, Liangping Zhao¹

Affiliations

¹ Department of Cardiology, The Fourth Hospital Affiliated to Soochow University, Medical Center of Soochow University, Suzhou Dushu Lake Hospital, 215000 Suzhou, Jiangsu, China.
² Department of Cardiology, The Second Affiliated Hospital of Soochow University, 215000 Suzhou, Jiangsu, China.
³ Emergency Department of Xuguan District, The Second Affiliated Hospital of Soochow University, 215000 Suzhou, Jiangsu, China.

Abstract

Background: Previous reports have indicated an association between red blood cell distribution width (RDW) and cardiovascular disease. However, few relevant studies exist on the relationship between RDW and aortic valve calcification (AVC). Explore the correlation and predictive value of RDW concerning the occurrence and severity of aortic valve calcification.

Methods: Blood examination results were analyzed from 1720 hospitalized patients at the Second Affiliated Hospital of Soochow University. Logistic regression analysis and the Cox proportional hazards model examined the relationship between RDW and the incidence and severity of AVC.

Results: The RDW value in cases with AVC was significantly higher than in the control group. Red cell distribution width-standard deviation (RDW-SD) and red cell distribution width-coefficient of variation (RDW-CV) increased with calcification severity. Both RDW-SD and RDW-CV demonstrated high predictive values for the occurrence of aortic valve calcification.

Conclusions: Red blood cell distribution width significantly correlated with the occurrence and severity of aortic valve calcification.

Keywords: aortic valve calcification; prediction; red blood cell distribution width.

Grants and funding

This study was supported by the Suzhou Medical Industry combination collaborative innovation research project (SLJ2022007), Postgraduate Research & Practice Innovation Program of Jiangsu Province (SJCX22-1510), Trust research project (HX201902) and Suzhou Medical Innovation Application Research Project (SKYD2023084).