AKR1B10 and digestive tumors development: a review

Yao Shen; Ailin Qiu; Xin Huang; Xiaosha Wen; Sundar Shehzadi; Yan He; Qian Hu; Jian Zhang; Dixian Luo; Shenghui Yang

doi:10.3389/fimmu.2024.1462174

AKR1B10 and digestive tumors development: a review

Front Immunol. 2024 Dec 16:15:1462174. doi: 10.3389/fimmu.2024.1462174. eCollection 2024.

Authors

Yao Shen¹, Ailin Qiu², Xin Huang^{3

4}, Xiaosha Wen³, Sundar Shehzadi³, Yan He², Qian Hu², Jian Zhang¹, Dixian Luo³, Shenghui Yang^{1

5}

Affiliations

¹ Medical School, Hunan University of Chinese Medicine, Changsha, Hunan, China.
² Institute of Pharmacy and Pharmacology, School of Pharmaceutical Science, Hengyang Medical School, University of South China, Hengyang, Hunan, China.
³ Laboratory Medicine Center, Shenzhen Luohu Hospital Group, the Third Affiliated Hospital (The Affiliated Luohu Hospital) of Shenzhen University, Shenzhen University, Shenzhen, Guangdong, China.
⁴ First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.
⁵ Department of Preventive Medicine, Medical School, Hunan University of Chinese Medicine, Changsha, Hunan, China.

Abstract

Aldo-keto reductase family 1 member B10 (AKR1B10) is a member of the AKR1B subfamily. It is mainly found in cytoplasm, and it is typically expressed in the stomach and intestines. Given that its expression is low or absent in other tissues, AKR1B10 is a potential diagnostic and therapeutic biomarker for various digestive system diseases. Here, we review recent research progress on AKR1B10 in digestive system tumors such as hepatocellular carcinoma, gastric carcinoma, colorectal carcinoma, pancreatic carcinoma, oral squamous cell carcinoma, laryngeal squamous cell carcinoma, cholangiocarcinoma, and nasopharyngeal carcinoma, over the last 5 years. We also discuss the current trends and future research directions for AKR1B10 in both oncological and non-oncological diseases to provide a scientific reference for further exploration of this gene.

Keywords: AKR1B10; digestive system tumors; mechanisms; metabolism; review.

Publication types

Review

MeSH terms

Aldo-Keto Reductases* / genetics
Aldo-Keto Reductases* / metabolism
Animals
Biomarkers, Tumor* / metabolism
Digestive System Neoplasms / diagnosis
Digestive System Neoplasms / enzymology
Digestive System Neoplasms / genetics
Digestive System Neoplasms / pathology
Gene Expression Regulation, Neoplastic
Humans

Substances

Aldo-Keto Reductases
AKR1B10 protein, human
Biomarkers, Tumor

Grants and funding

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This work was supported by grants from the Shenzhen University Medical-Engineering Interdisciplinary Research Fund Project (2023YG022); the 2023 International Science and Technology Independent Cooperation Project (GJHZ20220913144213025); Shenzhen Natural Science Foundation Project (JCYJ20240813114502004); Open Fund for Hunan Provincial Key Laboratory of Integrative Pathogen Biology in Chinese and Western Medicine (2022KFJJ08); and Hunan Province Chinese Medicine Research Program Project (2021031).