Dual-plasmonic eccentric nanostructure with prominent colorimetric and photothermal performance to detect zearalenone by dual signal immunochromatography assay

Yangyang Lu; Xuechi Yin; Mei Li; Wanlu Ma; Sining Du; Zixuan Wang; Nannan Qiu; Xubo Zhao

doi:10.1016/j.talanta.2024.127487

Dual-plasmonic eccentric nanostructure with prominent colorimetric and photothermal performance to detect zearalenone by dual signal immunochromatography assay

Talanta. 2024 Dec 29:286:127487. doi: 10.1016/j.talanta.2024.127487. Online ahead of print.

Authors

Yangyang Lu¹, Xuechi Yin¹, Mei Li¹, Wanlu Ma¹, Sining Du¹, Zixuan Wang¹, Nannan Qiu², Xubo Zhao³

Affiliations

¹ College of Food Science and Engineering, Northwest A&F University, Yangling, 712100, Shaanxi, China.
² NHC Key Laboratory of Food Safety Risk Assessment, Chinese Academy of Medical Science (2019RU014), China National Center for Food Safety Risk Assessment, Beijing, 100021, China. Electronic address: qiunannan@cfsa.net.cn.
³ College of Food Science and Engineering, Northwest A&F University, Yangling, 712100, Shaanxi, China; Laboratory of Quality & Safety Risk Assessment for Agro-Products (Yangling), Ministry of Agriculture and Rural Affairs of the People's Republic of China, Yangling, 712100, China. Electronic address: zhxubo@nwafu.edu.cn.

PMID: 39736205
DOI: 10.1016/j.talanta.2024.127487

Abstract

In the study, an eccentric heterogeneous core-shell nanomaterial Au@Cu_2-xSe was simply and rapidly synthesized. This novel nano-structure exhibits superior colorimetric intensity, enhanced antibody coupling efficiency, and strong broadband absorption across the visible to near-infrared spectrum, with a photothermal conversion efficiency of 59.40%. As proof of concept, we applied Au@Cu_2-xSe as a signal amplification marker in LFIA for the rapid detection of zearalenone (ZEN), enabling dual-mode quantitative detection via colorimetric and photothermal signals (CM/PT). The Au@Cu_2-xSe-LFIA demonstrated a cut-off value of 10 ng/mL in colorimetric mode and 5 ng/mL in photothermal mode, representing a two fold increase in sensitivity compared to traditional AuNPs-based LFIAs. The outstanding colorimetric signal and prominent photothermal signal make the proposed Au@Cu_2-xSe nanomaterial show better application prospects in CM/PT mode detection in LFIA, providing broad application prospects for the broad-spectrum detection of mycotoxins in food in the future.

Keywords: Dual signal; Dual-plasmonic eccentric nanostructure; Lateral flow immunoassay; Mycotoxin; Zearalenone.