The utilization of bone scaffold implants represents a promising approach for repairing substantial bone defects. In recent years, various traditional scaffold structures have been developed and, with advances in materials biology and computer technology, novel scaffold designs are now being evaluated. This study investigated the effects of a novel scaffold unit cell design (Hexanoid) through a computational framework, comparing its performance to that of four well-known scaffold designs. A finite element analysis numerical simulation and mechanical testing were conducted to analyze the dynamic bone ingrowth process and the mechanical strength of the different scaffold designs. Bone formation within the Ti-6Al-4V metal scaffolds was simulated based on the theory of bone remodeling. The outcomes of the study reveal that the novel scaffold design (Hexanoid) attains a notably elevated ultimate bone volume fraction (∼27%), it outperformed conventional unit-cell designs found in extant literature, such as cubic design with 19.1% and circular design with 16.9% in relation to the bone-to-cavity volume ratio. This novel structure also has comparable mechanical strength to that of human compact bone tissue. While the design was not optimal in every category, it provided a very satisfactory overall performance regarding certain key aspects of bone performances in comparison with the five scaffold structures evaluated. Although limitations exist in this project, similar methodologies can also be applied in the primary evaluation of new scaffold structures, resulting in improved efficiency and effectiveness. In future research, the results of this project may be integrated with clinical rehabilitation processes to offer a critical evaluation for optimization of additional novel scaffold unit-cell structure designs.
Keywords: bone ingrowth simulation; bone scaffold; finite element analysis (FEA); scaffold unit cell design.
Copyright 2023, Mary Ann Liebert, Inc., publishers.