Novel transition metal-free synthetic protocols toward the construction of 2,3-dihydrobenzofurans: a recent update

Aqsa Mushtaq; Muhammad Irfan; Atta Ul Haq; Asim Mansha; Samreen Gul Khan; Ameer Fawad Zahoor; Bushra Parveen; Ali Irfan; Katarzyna Kotwica-Mojzych; Mariola Glowacka; Mariusz Mojzych

doi:10.3389/fchem.2024.1470861

Novel transition metal-free synthetic protocols toward the construction of 2,3-dihydrobenzofurans: a recent update

Front Chem. 2024 Dec 13:12:1470861. doi: 10.3389/fchem.2024.1470861. eCollection 2024.

Affiliations

¹ Department of Chemistry, Government College University Faisalabad, Faisalabad, Pakistan.
² Department of Pharmaceutics, Government College University, Faisalabad, Pakistan.
³ Department of Basic Sciences, Department of Histology, Embriology and Cytophysiology, Medical University of Lublin, Lublin, Poland.
⁴ Faculty of Health Sciences Collegium Medicum, The Mazovian Academy in Plock, Płock, Poland.

Abstract

2,3-Dihydrobenzofurans are noteworthy scaffolds in organic and medicinal chemistry, constituting the structural framework of many of the varied medicinally active organic compounds. Moreover, a diverse variety of biologically potent natural products also contain this heterocyclic nucleus. Reflecting on the wide biological substantiality of dihydrobenzofurans, several innovative and facile synthetic developments are evolving to achieve these heterocycles. This review summarizes the transition-metal-free, efficient, and novel synthetic pathways toward constructing the dihydrobenzofuran nucleus established after 2020.

Keywords: catalyst free; dihydrobenzofurans; organocatalyzed; photocatalytic; transition metal-free.

Publication types

Review

Grants and funding

The author(s) declare that financial support was received for the research, authorship, and/or publication of this article. The research was partly financed by research projects: Collegium Medicum, the Mazovian Academy in Plock, and the Medical University of Lublin (DS 730).