Ultrasound characteristics and risk factors of female patients with pelvic varicose veins and concomitant chronic pelvic pain

Binyu Zheng; Gaorui Liu; Yong Liu

doi:10.1016/j.jvsv.2024.102165

Ultrasound characteristics and risk factors of female patients with pelvic varicose veins and concomitant chronic pelvic pain

J Vasc Surg Venous Lymphat Disord. 2024 Dec 27:102165. doi: 10.1016/j.jvsv.2024.102165. Online ahead of print.

Authors

Binyu Zheng¹, Gaorui Liu², Yong Liu³

Affiliations

¹ Beijing Shijitan Hospital, No.10 Tieyi Road, Haidian District, Beijing, China, 100038.
² Western Sydney Vascular, Level 3, Suite 2/20-22 Mons Road, Westmead, NSW Australia, 2145.
³ Beijing Shijitan Hospital, No.10 Tieyi Road, Haidian District, Beijing, China, 100038. Electronic address: liuy@bjsjth.cn.

PMID: 39733829
DOI: 10.1016/j.jvsv.2024.102165

Abstract

Objective: The study aims to elucidate clinical and ultrasonographic characteristics of female patients diagnosed with pelvic varicose veins (PVV) and to assess potential risk factors associated with incidences of chronic pelvic pain (CPP) in this population.

Methods: Clinical and ultrasound data were retrospectively collected from female patients with PVV at Beijing Shijitan Hospital between December 2017 and October 2022. Patient cohorts were divided into two groups based on whether they had been experiencing non-periodic pelvic pain over six months, consistent with the symptoms of CPP. Comparative analyses were conducted between the two groups, utilizing both univariate and multivariate logistic regression methodologies to identify risk factors for CPP.

Results: (1) The study included a total of 236 patients: 89 patients in the CPP group and 147 patients in the non-CPP group. No statistically significant differences were found between the two groups with regard to demographic parameters including age, height, weight, age of menarche, and number of pregnancies and births. However, the CPP group showed a higher menstrual volume score and a greater incidence of varicose veins, coupled with a lower Body Mass Index (BMI). (2) Transabdominal ultrasonography revealed that patients with CPP had a significantly larger diameter in the left ovarian vein (6.2 ± 1.9 mm vs 5.0 ±2.3mm, P <0.05), and a higher prevalence of left internal iliac vein incompetence (21.3 vs 8.8%). Moreover, positive rates for left ovarian vein incompetence were markedly higher (94.4% vs 23.1%, P <0.05) even in the absence of left common iliac vein compression and nutcracker phenomenon. (3) Multivariate logistic regression analysis discerned that the left ovarian vein reflux (Odds Ratio [OR] = 9.102, 95% Confidence Interval [CI]: 4.578-18.099; P <0.05), lower BMI (OR= 0.646, 95% CI: 0.502-0.83; P <0.05), elevated menstrual bleeding (OR = 1.182, 95% CI: 1.131-1.234; P <0.05), and concomitant varicose veins (OR= 3.140, 95% CI:1.067-9.273; P <0.05) are independent risk factors for the manifestations of CPP in our patient cohorts.

Conclusions: Ultrasonography serves as an efficacious modality for evaluating abdomino-pelvic vascular pathology in PVV patients. Notably, left ovarian vein and internal iliac vein incompetence emerge as independent risk factors for CPP, thus offering a pivotal point of reference for clinical diagnosis and therapeutic management of PVV.