Impact of IL13 genetic polymorphisms on COPD susceptibility in the Chinese Han population

Zehua Yang; Yamei Zheng; Jie Zhao; Yi Zhong; Lei Zhang; Haihong Wu; Tian Xie; Yipeng Ding

doi:10.1016/j.rmed.2024.107923

Impact of IL13 genetic polymorphisms on COPD susceptibility in the Chinese Han population

Respir Med. 2024 Dec 27:237:107923. doi: 10.1016/j.rmed.2024.107923. Online ahead of print.

Authors

Zehua Yang¹, Yamei Zheng¹, Jie Zhao¹, Yi Zhong², Lei Zhang¹, Haihong Wu¹, Tian Xie³, Yipeng Ding⁴

Affiliations

¹ Department of Pulmonary and Critical Care Medicine, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Haikou, 570311, Hainan, China.
² Department of General Practice, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Haikou, 570311, Hainan, China.
³ Department of Pulmonary and Critical Care Medicine, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Haikou, 570311, Hainan, China. Electronic address: hpphxietian@163.com.
⁴ Department of Pulmonary and Critical Care Medicine, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Haikou, 570311, Hainan, China. Electronic address: ypding@yeah.net.

PMID: 39733814
DOI: 10.1016/j.rmed.2024.107923

Abstract

Background: Chronic obstructive pulmonary disease (COPD) is characterized by persistent respiratory symptoms and airflow limitation. Interleukin-13 (IL13), associated with T-helper type 2 cells, plays a crucial role in COPD pathophysiology. This study aimed to investigate the relationship of single nucleotide polymorphisms (SNPs) in IL13 to COPD risk.

Methods: Five candidate SNPs of IL13 were genotyped using MassARRAY iPLEX platform in a cohort of472 COPD patients and 472 healthy controls. Logistic regression analysis was used to calculate odds ratios (ORs) and 95 % confidence intervals (CIs). Additionally, Multifactor dimensionality reduction (MDR) software was utilized to assess the combined impact of SNP-SNP interactions on COPD risk.

Results: IL13 rs20541 (OR: 1.24, p: 0.028), rs1295685 (OR: 1.31, p: 0.006), rs848 (OR: 1.27, p: 0.016), and rs847 (OR: 1.30, p: 0.007) were associated with COPD risk. Moreover, IL13 variants were related to the increased COPD risk in females, individuals aged ≥68 year, non-smokers or non-drinkers. The optimal multi-locus model was identified as the combination of rs20541 and rs1295685.

Conclusion: Our findings indicated the association between IL13 variants and an elevated risk of developing COPD, especially rs1295685 and rs847. These findings could have implications for understanding the role of IL13 variants in COPD predisposition.

Keywords: COPD; IL13; SNP-SNP; Stratified analyses; Susceptibility.