Mortality rates and risk factors associated with mortality in patients with stenotrophomonas maltophilia primary Bacteraemia and Pneumonia

Mürşit Hasbek; Özlem Aldemir; Yasemin Çakır Kıymaz; Cihad Baysal; Dilara Yıldırım; Seyit Ali Büyüktuna

doi:10.1016/j.diagmicrobio.2024.116664

Mortality rates and risk factors associated with mortality in patients with stenotrophomonas maltophilia primary Bacteraemia and Pneumonia

Diagn Microbiol Infect Dis. 2024 Dec 21;111(3):116664. doi: 10.1016/j.diagmicrobio.2024.116664. Online ahead of print.

Authors

Mürşit Hasbek¹, Özlem Aldemir², Yasemin Çakır Kıymaz³, Cihad Baysal³, Dilara Yıldırım⁴, Seyit Ali Büyüktuna³

Affiliations

¹ Department of Medical Microbiology, Sivas Cumhuriyet University Faculty of Medicine,Sivas, Turkey. Electronic address: mursithasbek@cumhuriyet.edu.tr.
² Infectious Diseases and Clinical Microbiology Clinic, Ministry of Health, Sivas Numune Hospital, Sivas, Turkey.
³ Department of Infectious Diseases and Clinical Microbiology, Sivas Cumhuriyet University Faculty of Medicine, Sivas, Turkey.
⁴ Medical Microbiology, Ministry of Health, Sivas Numune Hospital, Sivas, Turkey.

PMID: 39729953
DOI: 10.1016/j.diagmicrobio.2024.116664

Abstract

This study aims to evaluate the risk factors associated with the mortality of S. maltophilia infections. Patients aged 18 years and older with S. maltophilia infection. Patients were divided into two groups primary bacteraemia and pneumonia. Of 176 S. maltophilia infections, 85 (48.2 %) were classified as bacteremia and 91 (51.8 %) as pneumonia. The mortality rate was 56 %, with no significant difference observed between the groups. Invasive mechanical ventilation, history of carbapenem use, and high Charlson Comorbidity Index (CCI) were significantly higher in the pneumonia group. In univariate analysis, higher Acute Physiology and Chronic Health Evaluation (APACHE) II score, higher Sequential Organ Failure Assessment (SOFA) score, and use of total parenteral nutrition (TPN) were identified as independent risk factors for 28-day mortality. This study demonstrates a mortality rate of 56 % in S. maltophilia infections and provides concrete data on risk factors for mortality.

Keywords: Mortality; Risk factors; Stenotrophomonas maltophilia.