Cytokinin Plays a Multifaceted Role in Ralstonia solanacearum-Triggered Plant Disease Development

Mol Plant Pathol. 2024 Dec;25(12):e70045. doi: 10.1111/mpp.70045.

Abstract

Cytokinin signalling plays both positive and negative roles in plant resistance to pathogens. It is not clear whether the role of cytokinin changes at the different stages of pathogen infection. Arabidopsis thaliana sequentially exhibits distinct root morphological symptoms during Ralstonia solanacearum infection, which offers a good system to investigate function of cytokinin in the whole pathogen infection process. Using this system, we found increase of cytokinin signalling by Lonely Guy 2 (LOG2) overexpression or depletion of type-A Arabidopsis Response Regulators (ARRs), negative regulators of cytokinin signalling pathway, promoted cell death, wilting symptom and bacterial growth, but attenuated primary root growth inhibition and lateral root formation. The decrease of cytokinin signalling by mutation on Isopentenyl Transferases (IPTs) inhibited root hair formation, cell death, wilting symptom and bacterial colonisation. Application of different concentration of exogenesis 6-benzylaminopurine (6-BA) showed first promoted, then decreased root hair formation. Moreover, application of 6-BA accelerated cell death but suppressed lateral root formation and primary root growth inhibition. The diverse roles of cytokinin in these different root disease phenotypes suggested function of cytokinin during plant responses to R. solanacearum is cell type-specific, which provides new insights on roles of cytokinin signalling in regulation on plant-pathogen interactions.

Keywords: Ralstonia solanacearum; bacterial wilt; cytokinin; plant immunity; root disease symptoms.

MeSH terms

  • Alkyl and Aryl Transferases / genetics
  • Alkyl and Aryl Transferases / metabolism
  • Arabidopsis Proteins / genetics
  • Arabidopsis Proteins / metabolism
  • Arabidopsis* / genetics
  • Arabidopsis* / growth & development
  • Arabidopsis* / microbiology
  • Benzyl Compounds / pharmacology
  • Cytokinins* / metabolism
  • Gene Expression Regulation, Plant / drug effects
  • Mutation / genetics
  • Plant Diseases* / microbiology
  • Plant Roots* / growth & development
  • Plant Roots* / microbiology
  • Purines / metabolism
  • Purines / pharmacology
  • Ralstonia solanacearum* / pathogenicity
  • Ralstonia solanacearum* / physiology
  • Signal Transduction

Substances

  • Cytokinins
  • Arabidopsis Proteins
  • Benzyl Compounds
  • Purines
  • benzylaminopurine
  • Alkyl and Aryl Transferases